NUR 643, Common

Topic: Sickle Cell Disease on Advanced Genetic Cures

Your paper should demonstrate depth, rigor, and scholarly synthesis, rather than a simple summary of information.

Scholarly Requirements

• Length: 810 double-spaced pages (body only)
• Font & Formatting: 12-point font, 1-inch margins, APA 7th edition
• Abstract: Required (APA format)
• References:
  • 1015 professional, peer-reviewed sources
  • Databases may include CINAHL, MEDLINE, PubMed, etc.
  • Unpublished or general internet sources may not exceed 10% of references
• APA 7th Edition formatting is required throughout (title page, abstract, headings, citations, references)

Students are expected to review and adhere to the course AI policy prior to beginning this assignment.

Required Paper Components

Your paper must include the following sections, clearly labeled using APA headings:

1. Abstract
   • Significance of the clinical problem
   • Epidemiology, demographics, prevalence/incidence
   • Impact on quality of life
   • Financial costs to patients and/or society
   • Relevance to advanced nursing and NP practice
2. Review of the Literature
   • Integration of nursing, medical, and allied health literature
   • Emphasis on current, evidence-based findings
   • Scholarly synthesis (not article-by-article summaries)
3. Definition of the Clinical Issue
   • Pathophysiology as appropriate
   • Symptoms and clinical presentation
   • Relevant physical findings
4. Differential Diagnosis
   • 4 Common and high-risk differentials
   • Incidence and prevalence
   • Distinguishing clinical features
5. Diagnostics
   • Appropriate laboratory tests, imaging, or diagnostic studies
   • Rationale for selection
   • Interpretation of findings
6. Holistic Management
   • Pharmacologic and non-pharmacologic management
   • Patient education and shared decision-making
   • Role and scope of the Nurse Practitioner
7. Summary Statement
   • Concise synthesis of key clinical and evidence-based points
8. References
   • APA 7th edition format

Optional Enhancements (Encouraged)

To strengthen scholarly impact and clinical relevance, you may include:

• Tables or boxes summarizing evidence or guidelines
• Charts or graphs representing epidemiologic data
• Figures or illustrations of relevant anatomy or physical findings
• Credible patient or provider educational resources
• A brief case study to contextualize the clinical problem

All visual elements must be appropriately cited and integrated into the paper. Please use the Rubrics.

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