Assignment: Immunologic Mechanisms in Advanced Pathophysiology
Learning Objectives
By the end of this assignment, students will be able to:
- Differentiate between innate, passive, active, and adaptive immunity.
- Apply immunologic principles to clinical scenarios.
- Analyze immune responses in acute and chronic conditions.
- Integrate pathophysiologic mechanisms into advanced nursing practice.
AACN Essentials Alignment
This assignment aligns with the following AACN Essentials (2021):
- Domain 1: Knowledge for Nursing Practice
- 1.1 Demonstrate an understanding of pathophysiologic mechanisms underlying health and illness.
- Domain 2: Person-Centered Care
- 2.2 Apply clinical reasoning and judgment in the provision of person-centered care.
- Domain 6: Interprofessional Partnerships
- 6.1 Communicate effectively with healthcare team members to optimize care.
Case Study-Based Questions
Case Study 1: Pediatric RSV Infection
A 6-month-old infant presents with wheezing, cough, and fever. The mother reports the child has not received any vaccinations yet. Nasal swab confirms RSV.
Questions:
- What type of immunity is primarily responsible for the infants initial response to RSV?
- If the infant received palivizumab (a monoclonal antibody), what type of immunity would that represent?
- Explain how adaptive immunity would develop in this infant over time.
Case Study 2: Adult with Hepatitis B Exposure
A 32-year-old nurse experiences a needlestick injury from a patient with active Hepatitis B. She receives Hepatitis B immunoglobulin and begins the Hepatitis B vaccine series.
Questions:
- What type of immunity is provided by the immunoglobulin?
- What type of immunity is developed from the vaccine?
- Describe the role of memory B cells in long-term protection.
Case Study 3: Autoimmune Thyroiditis
A 45-year-old woman is diagnosed with Hashimotos thyroiditis. Lab results show elevated anti-thyroid peroxidase antibodies.
Questions:
- Which arm of the immune system is dysregulated in autoimmune thyroiditis?
- How does adaptive immunity contribute to tissue damage in this condition?
- What are the implications for APN management of autoimmune diseases? PLEASE USE LESS THEN 10% AI PLEASE.. SEE ATTACHED RUBRIC. PLEASE ANSWER THE THREE QUESTIONS PROVIDED FOR EVERY CASE STUDIES.
Requirements:
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