Draft #1 Revised for HCA695

So, I had had you write a draft for my HCA695 course with specific instructions and I will upload that paper that I submitted and his feedback. Keep in mind I have to put this into IRB. I have attached the draft you created and then Im going to paste the instructions for the draft he wanted as well.

Draft 1 Submission Checklist (PICO-Aligned)

General Formatting

NO front page start directly with your content.

Header: Include names, dates, and course number.

Footer or Header: Add page number.

Title: Use ALL CAPS and bold.

Times new Romas, 12 font, line spacing 2.0.

No subheadings, as it is one page only.

Content Requirements

Introduction:

Exactly one page (not less, not more).

Written in past tense and present perfect tense for at least 85% of the text.

Must follow PICO structure:

Population (P): Who is being studied?

Intervention (I): What is being tested?

Comparison (C): What is the alternative or control?

Outcome (O): What measurable results are expected?

Outcomes must include exact metrics (e.g., HbA1c (%), blood pressure (mmHg), medication adherence rate 80%, readmission rate (%).

Include 45 valid references:

Published 20152026.

Must include DOI or exact website link.

Research Purpose:

Clearly state the goal using PICO elements.

Hypothesis:

Must align with PICO and include Intervention, Population, Comparison, Outcome, with metrics.

Methodology:

Provide one concise sentence describing the design.

NO history section.

Follow the example posted next to the Draft 1 Icon.

Submission Instructions

Submit two separate files:

WORD Text file: One page of content.

References file: References section only, on a seperate document.

And this was his feedback to the draft and references I have attached:

“I just saw it and you must convert the tense to present and future tense in particular in the purpose and you must have a hypothesis. Also NEVER use reference for your purpose and hypothesis

And are missing the semi structured interview !!!!! That is why you are applying to the IRB and methods is lit review + interview

he research purpose was to evaluate whether psilocybin-assisted therapy reduces alcohol consumption and improves treatment outcomes more effectively than standard care in adults with AUD. The hypothesis stated that patients receiving psilocybin-assisted therapy would demonstrate a ?30% reduction in percentage of heavy drinking days, maintain abstinence rates ?40% at 32-week follow-up, and show decreased neural reactivity to alcohol cues (measured as reduced activation in brain regions associated with craving, including the ventral striatum and prefrontal cortex) compared to the control group receiving standard care (Pagni et al., 2024; Rieser et al., 2025). The methodology employed randomized controlled trial designs with blinded outcome assessments (Rieser et al., 2025). The evidence base included multiple peerreviewed studies published between 2015 and 2025, including phase 2 clinical trials demonstrating psilocybin’s safety and efficacy profile (Rieser et al., 2025), neuroimaging studies revealing biological mechanisms of action (Pagni et al., 2024), and systematic reviews synthesizing therapeutic effects across substance use disorders (De Veen et al., 2017; van der Meer et al., 2023). This research addressed a critical gap in addiction treatment by providing rigorous comparative data on psilocybin-assisted therapy’s effectiveness for AUD, contributing to the growing body of evidence supporting psychedelic-assisted therapies for treatment-resistant mental health and addiction conditions.

Take care” Instructions from my professor.